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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Eur J Neurosci. 2013 Apr 11;38(1):2078–2088. doi: 10.1111/ejn.12209

Figure 6. Analysis of the interaction between reinforcing electrical stimulation and DA transients.

Figure 6

Left Panels. Theoretical analysis of DA release according to Montague et al. (2004). Simulated electrically evoked DA response using Equation 2 and A0 = 0.03 μM, Km = 0.02 μM, and Vmax = 1.0 μM/s (A). Time course of variable [DA]p (B). Time course of facilitation (f1) and depression (d1 and d2) terms altering [DA]p (C). See Methods for details. Right Panels. Empirical analysis of DA transients. Transient amplitude (D). Intertransient interval (ITI) (E). Electrical stimulation was applied at 5 s of the 300-s recording epoch for characterizing DA transients; thus, 0-150 s is the stimulation bin and 150-300 s is the no-stimulation bin. Statistical analysis of the median was performed by Wilcoxon’s ranked sum test. n.s., not significant at p < 0.05.