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Effect of mitoTEMPO on human melanoma growth in nude mice. Nude mice were injected with A375 human melanoma cells, and after tumor was well established and growing, we have implanted osmotic pumps with saline (vehicle) or with mitoTEMPO (1.5 mg/kg/day). MitoTEMPO significantly attenuated the tumor size at days 9 and 12 compared with the saline group (*p<0.05 vs. saline, n=7). Insert demonstrates significant inhibition of the tumor growth rate by 12-day mitoTEMPO infusion.
