Tab. 3.
Summary of the dose-dependent assay on 60 cancer cell lines
| GI50, μM | TGI, μM | LC50, μM | |||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| Range | Range | Range | The most sensitive cell line | GI50/TGI of the most sensitive cell line | |||||
| Cpd. | Na | (min – max) | MG_MID | (min – max) | MG_MID | (min – max) | MG_MID | ||
| 4e | 60 | 2.62 to 32.60 | 12 | 6.10 to 80.20 | 40.74 | 26.30 to 98.70 | 85.11 | SK-MEL-5 /melanoma/ | 2.62 / 6.90 |
|
| |||||||||
| 4f | 58 | 1.26 to 17.70 | 4.19 | 2.85 to 76.30 | 14.79 | 5.34 to 93.00 | 47.86 | SK-MEL-5 /melanoma/ | 1.52 / 2.85 |
|
| |||||||||
| 4ib | 58 | 0.16 to 41.40 | 1.95 | 1.09 to 50.40 | 10.96 | 4.14 to 92.40 | 42.66 | HS 578T /breast cancer/ | 0.27 / 1.09 |
| (0.22 to 5.72) | (1.7) | (1.51 to 47.10) | (8.51) | (4.93 to 86.60) | (38.02) | UACC-257 /melanoma/ | (0.22 / 1.82) | ||
a
N, Number of human tumor cell lines;
b
The results of repeated testing are in parenthesis.