Tab. 1.
Effect of CPP against carrageenan-induced rat paw edema in rats
| Treatment (dose, mg/kg, route) |
Mean Paw Volume (mL.) ± SEM
|
PWT in Randall-Selitto assay at 3 h (g ± SEM) (% increase) | |||
|---|---|---|---|---|---|
| 0 h | 1 h | 2 h | 3 h | ||
| Vehicle control | 2.60 ± 0.07 | 3.65 ± 0.21 | 4.81 ± 0.21 | 5.23 ± 0.13 | 66.00 ± 7.8 |
| Celecoxib (10, p.o.) | 2.75 ± 0.07 | 3.55 ± 0.15 (23.44) | 4.43 ± 0.17 (24.04) | 4.18c ± 0.29 (45.79) | 90.00c ± 7.9 (36.4) |
| CPP (50, p.o.) | 2.79 ± 0.07 | 3.70 ± 0.19 (12.76) | 4.72 ± 0.17 (12.81) | 4.84b ± 0.37 (21.83) | 74.3 ± 4.08 (12.63) |
| CPP (100, p.o.) | 2.72 ± 0.10 | 3.24 ± 0.13 (12.28) | 4.28 ± 0.05 (29.54) | 4.48 ± 0.09 (33.19) | 75.00a ± 4.14 (16.66) |
| CPP (200, p.o.) | 2.47± 0.10 | 3.30 ± 0.10 (21.05) | 3.91c± 0.14 (37.27) | 4.05c± 0.03 (39.97) | 81.0c ± 0.97 (20. 73) |
n=6, Data is represented as Mean paw volume (ml.) ± SEM. and was analyzed by Two-way repeated measures ANOVA followed by Bonferroni posttests. Significance represented as
a
P < 0.05,
b
P < 0.01,
c
P < 0.001 as compared to vehicle at respective time point. PWT…Paw withdrawal Threshold.