Tab. 2.
Effect of CPP in cotton pellet granuloma- and acetic acid-induced writhing model in rats
| Treatment | Mean weight of cotton pellet granuloma ± S.E.M. (% Inhibition) | Mean number of writhes against acetic acid (% analgesia) |
|---|---|---|
| Vehicle control | 44.67 ± 1.60 | 29.17 ± 0.48 |
| Celecoxib (10, p.o.) | 25.23 ± 0.47c (43.51) | 13.83 ± 0.60c (52.59) |
| CPP (50, p.o.) | 32.47 ± 0.49c (27.31) | 25.33 ± 1.05 (13.16) |
| CPP (100, p.o.) | 29.30 ± 0.81c (34.40) | 23.83 ± 1.30 (18.31) |
| CPP (200, p.o.) | 27.28 ± 1.25c (38.92) | 22.00 ± 1.53a (24.58) |
n=6, Data is represented as Mean value ± SEM. and was analyzed separately for each parameter by One-way ANOVA followed by Dunnett’s t test. Significance represented as
a
P < 0.05,
c
P < 0.001 as compared to vehicle control.