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. 2013 Jun;33(12):2470–2484. doi: 10.1128/MCB.01593-12

Fig 7.

Fig 7

BCR-induced RAC activation requires SOS but not allosteric activation of SOS1. (A) RAC activation in response to high anti-BCR dosage is measured by a RAC pulldown assay. (B) RAC activation in stably hSOS1-reconstituted DT40 cells is measured by a RAC pulldown assay. Low anti-BCR dosage is used for stimulation. Percentages relative to the wild-type maximum activation are shown. Data are representative of two experiments.