Table 1.
Proteins and corresponding N. crassa mutant strains employed
| Subunit and strain | Protein in Homo sapiens | Property(ies) | Assembly and intermediatea | Activity | Reference |
|---|---|---|---|---|---|
| 78 kDa; nuo78 | NDUFS1 | N4, N5, N1b | No; a | No | 29 |
| 51 kDa; nuo51 | NDUFV1 | N3, NADH, FMN | Yes | No | 18 |
| 24 kDa; nuo24 | NDUFV2 | N1a | Yes | No | 17 |
| 21.3a kDa; nuo21.3a | NDUFA7 | Yes | Yes | 27 | |
| 21.3c kDa; nuo21.3c | NDUFS8 | N6a, N6b | No; MA | No | 28 |
| 21 kDa; nuo21 | NDUFS4 | Phosphorylation | Yes | Yes | 26 |
| 20.8 kDa; nuo20.8 | NDUFA8 | No; PA, small | No | 42 | |
| 18.4 kDa; nuo18.4 | NDUFS6 | Zinc binding | Yes | Yes | This work |
| 14 kDa; nuo14 | NDUFA13 | Proapoptotic | No; PA, small | No | 14 |
| 13.4 kDa; nuo13.4 | NDUFA12 | Nitrosylated | Yes | Yes | This work |
| 12.3 kDa; nuo12.3 | NDUFB10 | No; PA, large | No | 25 | |
| 9.8 kDa; nuo9.8 | NDUFA1 | No; PA, small | No | 24 | |
| 13.4L; 13.4L | NDUFAF2 | Assembly factor | Yes | Yes | This work |
a
a, intermediate that contains the P and Q modules of complex I; PA, peripheral arm intermediate; MA, membrane arm intermediate; small, small intermediate of the membrane arm; large, large intermediate of the membrane arm.