Table 1.
Clinical and virologic characteristic of CHB-M, CHB-S, and ACLF patientsa
| Characteristic | CHB-M | CHB-S | ACLF | P value |
|---|---|---|---|---|
| No. of patients | 145 | 106 | 122 | |
| Mean ± SD age (yr) | 40.4 ± 13.5 | 38.6 ± 13.8 | 45.2 ± 11.3 | <0.01 |
| Gender (no. of M/no. of F) | 127/18 | 91/15 | 100/21 | >0.05 |
| No. (%) of patients with the following HBV genotype: | ||||
| B | 32 (22.1) | 30 (28.3) | 35 (28.7) | >0.05 |
| C | 110 (75.9) | 75 (70.8) | 87 (71.3) | >0.05 |
| No. (%) of patients with the HBcL60V variation | 16 (11.0) | 24 (22.6) | 31 (25.4) | <0.01 |
| No. (%) of patients HBeAg positive | 98 (67.6) | 45 (42.5) | 31 (25.4) | <0.01 |
| No. of HBV DNA copies/ml | ||||
| Mean | 2.5 × 107 | 1.1 × 107 | 1.2 × 107 | >0.05 |
| Range | 1,282–1.6 × 109 | 500–2.6 × 108 | 500–5.3 × 108 | |
| Mean ± SD concn (IU/liter) | ||||
| ALT | 145.8 ± 218.6 | 457.0 ± 382.3 | 258.5 ± 394.0 | <0.01 |
| AST | 101.8 ± 120.5 | 297.4 ± 280.0 | 307.9 ± 446.3 | <0.01 |
a
HBV, hepatitis B virus; CHB-M, mild chronic hepatitis B; CHB-S, severe chronic hepatitis B; ACLF, acute-on-chronic liver failure; M, male; F, female; HBeAg, hepatitis B virus e antigen; ALT, alanine aminotransferase; AST, aspartate aminotransferase.