Fig 10.

Disabling any of the individual EBOV IRADs by a single point mutation each results in effective secretion of chemokines and cytokines by infected DC. The levels of CXCL chemokines (row 1 from top), CCL chemokines (row 2), and cytokines, including IFNs (rows 3 and 4), in supernatants of DC infected with the VP24 and VP35 EBOV mutants, HPIV3 and HPIV3/ΔF-HN/EboGP, normalized to that for DC infected with wt EBOV. The 100% levels in DC infected by wt EBOV are shown by the red lines. Shown are results of two independent experiments, in which DC from subject 1 or DC from subject 2 were used.