Table 2.
Predicted interactions between SFV DIII-stem and the SFV E1 core trimer
| Structure | Residue(s) at which core trimer interactsa |
|---|---|
| Side chain | |
| DIII | |
| Asp311 | Thr41 (hydrogen bond) |
| His331 | Asn149 (hydrogen bond) |
| His333b | Asp145 (salt bridge) |
| Stem | |
| His386 | Glu246 (salt bridge) |
| Tyr390 | Pro237 (hydrophobic) |
| Main chain | |
| DIII | |
| Ser309 | Leu44 |
| Gln340b | Phe257, Gly258 |
| Stem | |
| Lys384 | Arg206 |
| His386 | Asp212 |
a
The type of predicted interaction is shown in parentheses. Note that for the results shown for the side chain, all interactions are with the side chain of the core trimer residue, except for Thr41, which interacts with the main chain. Note that for the results shown for the main chain, Leu44, Phe257, and Gly258 interact via the main chain of the core trimer, and Arg206 and Asp212 interact via their side chains.
b
Residues that differ between SFV and CHIKV DIII-stem (Met333 and Arg340 in CHIKV). Note that for His333, the predicted core trimer-interacting partner also differs between SFV (Asp145) and CHIKV (Thr145).