Fig 4.

HDAC1 colocalizes with viral replication compartments. Primary macrophages were infected at an MOI of 10 with wild-type or orf36 mutant MHV68 viruses. At 16 hpi, cells were fixed and stained with DAPI (4′,6-diamidino-2-phenylindole) and antibodies directed against MHV68 ssDBP and HDAC1. Images were merged, with HDAC1 in green, ssDBP in red, and DAPI in blue. Colocalization was tested using Pearson's correlation coefficient.