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. Author manuscript; available in PMC: 2013 Jul 3.
Published in final edited form as: J Nucl Med. 2012 May 10;53(6):961–968. doi: 10.2967/jnumed.111.092361

Figure 5.

Figure 5

Copper excretion in LEC−/− rats after reconstitution of hepatic Atp7b with transplanted healthy LEA hepatocytes. LEC−/− rats are shown 3–12 mo after cell transplantation. (A) Immunostaining for hepatic Atp7b in untreated control LEC−/− rat, healthy donor LEA rat, and LEC−/− rat with areas of transplanted hepatocytes containing Atp7b (arrow, panel on right) (×100; 4′,6-diamidino-2-phenylindole counterstain of nuclei). (B) Bile 64Cu excretion over 1 h in untreated control LEC−/− rats, healthy LEA rats, and LEC−/− rats after transplantation of LEA rat hepatocytes. (C) Analysis of hepatic 64Cu activity by small-animal PET during 1 h in representative animals. Tx = therapy.