A–D, JB6 cells were pretreated with quercitrin (10, 20, and 40 μM) or acetone for 1 h prior UVB exposure. After 2 h, the cells were collected for Comet assay. E–H, The animal treatment is the same as that in Fig. 1. At 1 day and 7 days of 6-week treatment, the mice were euthanized and small pieces of skin tissues/mouse was isolated and subjected to Comet assay. A, B, E, and F, Percentage of DNA in tail over that in total. C, D, G, and H, Tail moment. * indicates a significant difference compared with control without UVB exposure (p<0.05). # indicates a significant difference compared with 240 mJ/cm2 (in vitro) or 75 mJ/cm2 (in vivo) of UVB exposure (p<0.05).