Table 2.
Multivariate odds ratios of prostate cancer and adiponectin levels by sequence variants in the adiponectin (ADIPOQ) gene in the Physicians' Health Study, 1982-2009.
| Total prostate cancer | log(Adiponectin) - μg/mL b | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP | Cases (n=1286) N (%) | Controls (n=1267) N (%) | OR a | 95% CI | p-for-trend | N | (n = 951) Mean (SD) | p-for-trend | |||
| 1 | rs266729 | CC | 636 (53) | 675 (57) | 1.00 | reference | -- | 483 | 8.78 (0.61) | ||
| CG | 477 (40) | 443 (37) | 1.14 | 0.97 | 1.36 | 340 | 8.67 (0.62) | ||||
| GG | 79 (7) | 65 (5) | 1.30 | 0.92 | 1.84 | 57 | 8.58 (0.53) | 0.001 | |||
| 0.049 | |||||||||||
| 2 | rs182052 | GG | 545 (45) | 564 (47) | 1.00 | reference | -- | 416 | 8.79 (0.63) | ||
| AG | 527 (43) | 524 (44) | 1.03 | 0.87 | 1.22 | 406 | 8.67 (0.62) | ||||
| AA | 147 (12) | 108 (9) | 1.42 | 1.08 | 1.87 | 90 | 8.61 (0.51) | 0.0009 | |||
| 0.04 | |||||||||||
| 3 | rs168681205 | GG | 1077 (87) | 1079 (88) | 1.00 | reference | 812 | 8.73 (0.63) | |||
| AG | 161 (13) | 138 (11) | 1.17 | 0.92 | 1.49 | 111 | 8.62 (0.58) | ||||
| AA | 5 (0.4) | 7 (0.6) | 0.74 | 0.23 | 2.33 | 3 | 8.93 (0.33) | 0.14 | |||
| 0.34 | |||||||||||
| 4 | rs168681209 | CC | 1014 (82) | 986 (80) | 1.00 | reference | 744 | 8.66 (0.63) | |||
| AC | 206 (17) | 230 (19) | 0.87 | 0.71 | 1.07 | 163 | 8.93 (0.52) | ||||
| AA | 13 (1) | 11 (1) | 1.13 | 0.51 | 2.55 | 10 | 9.17 (0.61) | <.0001 | |||
| 0.30 | |||||||||||
| 5 | rs822391 | TT | 855 (69) | 779 (64) | 1.00 | reference | -- | 622 | 8.71 (0.62) | ||
| CT | 346 (28) | 389 (32) | 0.81 | 0.68 | 0.96 | 270 | 8.74 (0.61) | ||||
| CC | 47 (4) | 52 (4) | 0.83 | 0.55 | 1.24 | 36 | 8.66 (0.77) | 0.82 | |||
| 0.02 | |||||||||||
| 6 | rs12495941 | GG | 508 (42) | 496 (42) | 1.00 | reference | 358 | 8.72 (0.61) | |||
| GT | 539 (45) | 531 (46) | 0.99 | 0.84 | 1.18 | 397 | 8.72 (0.65) | ||||
| TT | 162 (13) | 148 (13) | 1.07 | 0.83 | 1.39 | 127 | 8.74 (0.49) | 0.87 | |||
| 0.70 | |||||||||||
| 7 | rs17366568 | GG | 920 (75) | 924 (77) | 1.00 | reference | 689 | 8.76 (0.60) | |||
| AG | 282 (23) | 256 (21) | 1.11 | 0.91 | 1.34 | 187 | 8.61 (0.63) | ||||
| AA | 17 (1) | 13 (1) | 1.31 | 0.63 | 2.71 | 12 | 8.44 (0.61) | 0.0003 | |||
| 0.23 | |||||||||||
| 8 | rs3821799 | CC | 383 (31) | 350 (29) | 1.00 | reference | -- | 282 | 8.66 (0.66) | ||
| CT | 601 (49) | 606 (50) | 0.90 | 0.75 | 1.08 | 441 | 8.73 (0.60) | ||||
| TT | 249 (20) | 259 (21) | 0.87 | 0.69 | 1.09 | 190 | 8.76 (0.62) | 0.09 | |||
| 0.20 | |||||||||||
| 9 | rs3774261 | GG | 462 (37) | 441 (37) | 1.00 | reference | -- | 343 | 8.63 (0.67) | ||
| AG | 596 (48) | 574 (48) | 0.98 | 0.83 | 1.17 | 431 | 8.74 (0.59) | ||||
| AA | 183 (15) | 193 (16) | 0.90 | 0.70 | 1.14 | 147 | 8.86 (0.59) | 0.0001 | |||
| 0.43 | |||||||||||
| 10 | rs17366743 | TT | 1154 (94) | 1136 (94) | 1.00 | reference | 850 | 8.72 (0.61) | |||
| CT/CC | 78 (6) | 73 (6.1) | 1.07 | 0.77 | 1.49 | 55 | 8.83 (0.63) | ||||
| 0.19 | |||||||||||
| 0.76 | |||||||||||
| 11 | rs2082940 | CC | 969 (80) | 907 (76) | 1.00 | reference | -- | 706 | 8.72 (0.64) | ||
| CT | 226 (19) | 260 (22) | 0.81 | 0.66 | 0.99 | 189 | 8.67 (0.58) | ||||
| TT | 14 (1) | 26 (2) | 0.51 | 0.27 | 0.98 | 17 | 9.05 (0.50) | 0.7 | |||
| 0.006 | |||||||||||
| 12 | rs7639352 | CC | 652 (54) | 650 (55) | 1.00 | reference | -- | 514 | 8.65 (0.65) | ||
| CT | 453 (38) | 428 (37) | 1.05 | 0.88 | 1.24 | 313 | 8.78 (0.54) | ||||
| TT | 98 (8) | 94 (8) | 1.04 | 0.76 | 1.40 | 70 | 8.90 (0.61) | <.0001 | |||
| 0.66 | |||||||||||
a
among Caucasians only, adjusted for age at randomization (yrs, continuous), cigarette smoking status (never, current, past) and time between blood draw & event date (yrs, continuous))
b
adjusted for age at randomization and body mass index among Caucasians, includes all controls and cases with > 5 years between blood draw & diagnosis