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. Author manuscript; available in PMC: 2014 Jan 17.
Published in final edited form as: Nature. 2013 Jan 17;493(7432):356–363. doi: 10.1038/nature11863

Figure 1. The FA pathway functions in ICL repair.

Figure 1

Upon detection of the crosslink, the core complex is activated and FANCL in the complex ubiquitylates the ID complex. The ID complex then coordinates the action of downstream repair factors, including nucleases and homologous recombination proteins, like the FA proteins BRCA2, FANCJ, PALB2, and RAD51C. Proteins that have been identified as mutated in FA patients are shown in color; factors known to participate in the pathway but are not clinically associated with FA are shown in grey. FANCJ, although not necessary for FANCD2 monoubiquitylation, may work at earlier steps than homologous recombination.