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. Author manuscript; available in PMC: 2013 Jul 3.
Published in final edited form as: J Immunol. 2007 Apr 15;178(8):4803–4810. doi: 10.4049/jimmunol.178.8.4803

FIGURE 2.

FIGURE 2

DCs from MRL/lpr mice fail to efficiently repress Sm-specific Ig secretion. LPS-stimulated (30 μg/ml) splenocytes (1 × 105 B cells) or purified B cells (1 × 105) were cocultured with the indicated ratios of BMDCs (A), or ex vivo splenic DCs (B). Secreted IgMa/κ levels were quantitated by ELISA from the day 4 culture supernatant. LPS-stimulated purified B cells (100%) secreted 1–10 μg/ml IgMa/κ. Data represent 14 (A) and 8 (B) MRL/lpr mice. (▲, Controls; ● B6, MRL/lpr).