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. Author manuscript; available in PMC: 2013 Jul 3.
Published in final edited form as: Annu Rev Pathol. 2011;6:395–423. doi: 10.1146/annurev.pathol.4.110807.092150

Figure 1.

Figure 1

Light photomicrographs illustrating various stages of developing glomerular lesions and tubulointerstitial disease in diabetic nephropathy. (a) A normal glomerulus. (b) Thickened basement membranes (arrowheads) and expanded mesangial regions (asterisks). (c) The nodular appearance of the mesangial regions characteristic of Kimmelstiel-Wilson lesions (asterisks). (d) The tubulointerstitial lesions include thickened tubular basement membrane (TBM), hyalinization of afferent arteriole (ART), and fibrosis of the interstitium (INT). Abbreviations: c, capillary lumen; En, endothelial cell; Ep, visceral epithelial cell (podocyte); Me, mesangium; US, urinary space.