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NTS PPG knockdown results in hyperphagia and increased body weight in chow-fed rats. A, B, Cumulative body weight change (A) and daily food intake (B) during the first 2 weeks of the study. C, D, Cumulative body weight change (C) and average daily food intake (D) for the 6-week duration of the study. E, F, Changes in fat mass (E) and lean mass (F) over time. Data are represented as mean ± SEM (n = 20 rats per group). *p < 0.05, **p < 0.01, ***p < 0.001 vs control.
