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Chronic ICV Ex9 results in hyperphagia, increased fat accumulation and glucose intolerance in chow- and HFD-fed rats. A, B, Cumulative body weight change (A) and food intake (B). C, D, Changes in fat mass (C) and lean mass (D). E, F, Intraperitoneal glucose tolerance. Data are represented as mean ± SEM (n = 10 rats per group). *p < 0.05, ***p < 0.001, Ex9 vs saline within chow or HFD.
