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. Author manuscript; available in PMC: 2014 Jan 15.
Published in final edited form as: Transplantation. 2013 Jan 15;95(1):48–53. doi: 10.1097/TP.0b013e3182782efc

Figure 2. MCMV-induced infiltration of NK and myeloid cells decreases after GCVprophylaxis.

Figure 2

(A–C) CD45+ cells from allografts at day 42 post-transplant were analyzed by flow cytometry for (A) NK cells (CD3−/CD49b+ cells), (B) myeloid cells (CD11b+/Gr-1+ cells), and (C) CD4+ and CD8+ T lymphocytes. CMV infected grafts showed significantly greater NK (** p<0.01) and myeloid (* p<0.05) infiltrates than uninfected grafts, and GCV prophylaxis decreased these infiltrates to levels statistically indistinguishable from uninfected grafts. The CD4+ and CD8+ lymphocyte frequencies were not significantly different between groups.

(D, E) The CD45+ cells in spleen (D) and liver (E) were analyzed for frequencies of CD4+,CD8+, CD3−/CD49b+, and Gr-1+ cells in transplant recipients receiving MCMV- grafts (No CMV), MCMV+ grafts (CMV), and MCMV+ grafts treated with ganciclovir (CMV+GCV). The frequencies of all cell types were similar between all groups, with the exception of splenic CD8+ cells which were statistically fewer in frequency in the spleens of the CMV+GCV group compared to the spleens from the No CMV group (* p<0.05).