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. Author manuscript; available in PMC: 2013 Jul 3.
Published in final edited form as: Hepatology. 2010 Aug;52(2):678–690. doi: 10.1002/hep.23721

Fig. 2.

Fig. 2

Tg expression of Cyp7a1 in the mouse liver prevented fatty liver. Female CYP7A1-tg mice were fed chow or an HFD for 4 months. Mice were fasted overnight. (A) The liver weight was determined. (B) H&E staining and Oil Red O staining of liver sections. Arrows indicate unstained lipid inclusions. (C,D) Hepatic cholesterol and TG contents. (E) Serum ALT levels in WT and CYP7A1-tg mice fed an HFD. Results are expressed as means and standard errors (n =8–10). *Statistically significant difference (P < 0.05) versus chow-fed WT mice; **statistically significant difference (P < 0.05) versus HFD-fed WT mice. Abbreviations: ALT, alanine aminotransferase; Tg, transgenic; WT, wild-type.