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Antiproliferative activities of 22a-b and parthenolide (PTL)a
| compound | DU-145 | HeLa | HL-60 | U-87 MG | NCI/ADR-RES | Vero |
|---|---|---|---|---|---|---|
| 22a | 29.1 ± 4.7 | 20.3 ± 6.0 | 5.5 ± 0.4 | 27.1 ± 4.8 | 80.9 ± 24.0 | 32.2 ± 7.0 |
| 22b | 21.6 ± 1.9 | 39.7 ± 16.4 | 7.8 ± 2.3 | 9.8 ± 1.4 | 25.4 ± 1.0 | 30.1 ± 5.5 |
| PTL | 8.9 ± 4.6 | 45.1 ± 3.7 | 9.3 ± 3.8 | 8.8 ± 2.1 | 57.6 ± 8.9 | 22.4 ± 1.5 |
Compounds were dosed to cells and incubated for 48 h. Viability was measured by Alamar Blue staining. Mean IC50 values ± S.D. (μM) are shown.
