Table 4.

Amino Acid Sites within the Envelope Protein That Were Found to Be Under Directional Selection

Site	Compositiona	MRCAb	Target	Inferred substitutionsc	DEPS EBF
51	S35V2T1	S	V	S0↔1T, S0↔2V	298.3
76	T36M2	T	M	M2↔0T	692.7
123	S33N3R2	S	N	N3↔0S, R2↔0S	6656.3
129	T33M4L1	T	M/T	L1↔0T, M4↔1T	>105/>105
146	T32A5S1	T	A/T	A5↔0T, S1↔0T	200.6/122.6
169	V34I4	V	I	I4↔0V	>105
222	A19S18L1	A	A	A0↔1L, A14↔6S	2558.1
227	S34P4	S	P	P4↔0S	>105
230	S34N4	S	N	N4↔0S	>105
367	A19S19	A	A	A11↔36S	1637.4
375	M36I2	M	I	I2↔0M	126.2
400	A35P2E1	A	P	A0↔1E, A0↔2P	1594.9
474	V33I5	V	I	I5↔0V	>105
483	L36M2	L	M	L0↔2M	318.8
484	A35V3	A	V	A0↔3V	1654.1

^aAmino acid composition at the site.

^bReconstructed most recent common ancestor (MRCA) at the site.

^cAmino acid substitutions inferred when A_b↔_cD indicates b substitutions from A to D and c substitutions from D to A.

^dEmpirical Bayes factor for evidence in favor of a directional selection model at the site for the target residue.

DEPS, directional evolution in protein sequences.