Representative pressure traces for five exposure groups (A). The signal was smoothed using Fast Fourier Transformation (FFT) band pass filter for the clarity of presentation. (B) Schematic representation of peak-trough analysis on overpressure recorded by brain sensor: Δpt is a sum of the first two peak-to-peak amplitudes. Results of peak-trough analysis: (C) Lethal groups (190, 250 and 290 kPa) have significantly higher Δpt (p<0.05) compared with non-lethal groups (130 and 230 kPa). There are no statistically significant differences between Δpt in respective non-lethal and lethal groups (p>0.05, marked with ampersand). (D) FFT analysis of the intracranial pressure profiles recorded by the sensor implanted in the brain. The high frequency component (peaks marked with arrows, >10 kHz) is present in the signal of lethal groups (190, 250, and 290 kPa).