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. 2013 Jul 1;30(13):1170–1176. doi: 10.1089/neu.2012.2691

FIG. 1.

FIG. 1.

Effects of hypothermia on the development of cortical lesion in controlled cortical impact (CCI) mice. (a) Left panels show representative hematoxylin & eosin (H&E)-stained sections obtained from the center of the brain legion in C57B6 mice subjected to CCI at the normothermic (CCI:37°C, n=9 mice) or hypothermic (CCI:33°C, n=9 mice) condition for 3 h, followed by 14-day recovery. Right panels show delineation of cortical lesion area (white area) from the corresponding images on the left by using the NIH Image J software. Bar=100 μm (b). The volume of brain lesion in CCI mice was quantified using a series of H&E stained sections spanning the entire cortical cavity as described in Methods. Statistical analysis showed a significant reduction in the averaged lesion volume in hypothermic vs. normothermic CCI groups. #p<0.05.