Table 2.
Genotype Frequencies of Selected Polymorphisms in PDCD6 Among UL and Controls and Their Association with UL Risk
| |
|
UL |
Controls |
Logistic regressiona |
|
|---|---|---|---|---|---|
| Genetic model | Genotype | N=295 (%) | N=436 (%) | OR (95% CI) | p-Value |
| rs4957014 G/T | |||||
| Codominant | T/T | 149 (50.5%) | 193 (44.3%) | 1.00 (reference) | 0.013 |
| G/T | 132 (44.8%) | 198 (45.4%) | 1.16 (0.85–1.57) | ||
| G/G | 14 (4.8%) | 45 (10.3%) | 2.48 (1.31–4.69) | ||
| Dominant | T/T | 149 (50.5%) | 193 (44.3%) | 1.00 (reference) | 0.097 |
| G/T-G/G | 146 (49.5%) | 243 (55.7%) | 1.28 (0.96–1.73) | ||
| Recessive | T/T-G/T | 281 (95.2%) | 391 (89.7%) | 1.00 (reference) | 0.005 |
| G/G | 14 (4.8%) | 45 (10.3%) | 2.31 (1.24–4.29) | ||
| Overdominant | T/T-G/G | 163 (55.2%) | 238 (54.6%) | 1.00 (reference) | 0.86 |
| G/T | 132 (44.8%) | 198 (45.4%) | 1.03 (0.76–1.38) | ||
| Log-additive | 1.35 (1.06–1.72) | 0.013 | |||
| rs3756712 G/T | |||||
| Codominant | T/T | 211 (71.5%) | 241 (55.3%) | 1.00 (reference) | <0.0001 |
| G/T | 72 (24.4%) | 155 (35.5%) | 1.88 (1.35–2.64) | ||
| G/G | 12 (4.1%) | 40 (9.2%) | 2.92 (1.49–5.71) | ||
| Dominant | T/T | 211 (71.5%) | 241 (55.3%) | 1.00 (reference) | <0.0001 |
| G/T-G/G | 84 (28.5%) | 195 (44.7%) | 2.03 (1.48–2.79) | ||
| Recessive | T/T-G/T | 283 (95.9%) | 396 (90.8%) | 1.00 (reference) | 0.0064 |
| G/G | 12 (4.1%) | 40 (9.2%) | 2.38 (1.23–4.62) | ||
| Overdominant | T/T-G/G | 223 (75.6%) | 281 (64.5%) | 1.00 (reference) | 0.0013 |
| G/T | 72 (24.4%) | 155 (35.5%) | 1.71 (1.23–2.38) | ||
| Log-additive | 1.80 (1.39–2.32) | <0.0001 | |||
N corresponds to the number of individuals.
a
Crude analysis.
Boldfaced values indicate a significant difference at the 0.05.