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. Author manuscript; available in PMC: 2013 Jul 3.
Published in final edited form as: J Clin Immunol. 2011 May 11;31(4):666–680. doi: 10.1007/s10875-011-9541-7

Figure 1.

Figure 1

MIF-KO mice display attenuated cytokine production in skin-draining LN cells after EC OVA exposure. Production of Th2 cytokines (IL-4, IL-5, and IL-13) are compromised in the MIF-KO system despite supplementation with IL-2. Mice were EC exposed to OVA on day 0 and axillary LNs were harvested on day 4. LN cells were restimulated in vitro with OVA. After 48 hours, cytokine levels in culture supernatants were measured. WT (n=5), MIF-KO (n=5). Each panel is representative of three separate experiments. Statistical significance was determined using an unpaired Student’s t test or ANOVA. Error bars represent one standard deviation from the mean. *** p<0.001, **p<0.01, *p<0.05.