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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Cell Signal. 2013 May 21;25(9):1895–1903. doi: 10.1016/j.cellsig.2013.05.018

Figure 1. Structure of HIFα Proteins.

Figure 1

HIF1α and HIF2α are both bHLH and PAS proteins and exhibit a high degree of similarity in their DNA and ARNT binding domains, and the C-terminal transcriptional activation domains. The N-terminal transactivation domains overlap with the oxygen dependent degradation domains containing two hydroxylation-sensitive proline residues. Numbers refer to percentage of amino acid sequence similarity between HIF1α and HIF2α.