Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
A) Under hypoxia HIF is transcriptionally active in a complex with ARNT, CBP, p300 and RNA polymerase II (POL II). B) The presence of oxygen allows for FIH-mediated asparaginyl (N) hydroxylation of the HIFα protein interfering with CBP or p300 interaction with the HIFα C-TAD and preventing target gene transcription.
