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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Cell Signal. 2013 May 21;25(9):1895–1903. doi: 10.1016/j.cellsig.2013.05.018

Figure 6. HIF enhanceosomes integrate pro-tumorigenic signaling pathways in response to tumor hypoxic stress.

Figure 6

HIFs interaction in enhanceosome transcriptional complexes with effectors of different signaling pathways (arrows) mediates the activation of a number of genes that promote tumorigenic processes under conditions of intratumoral hypoxia and inflammation. Because of the dependence of gene expression upon HIF/co-factor interaction, inhibition of HIF enhanceosome formation inhibits gene expression mediated by a number of protumorigenic pathways activated in the tumor microenvironment.