Table 2. Factors associated with discontinuation of OCs among HIV-infected women in Uganda and Zimbabwe.
Additional factors investigated which were not significant in bivariable models include: living with a partner, education, parity, currently breastfeeding, primary partner’s HIV status, primary partner spent nights away, alcohol use, severe headaches, nausea, breast tenderness, bleeding between periods, abnormal vaginal discharge, current vaginal infection (TV, BV, Candida, unexplained fever, excessive night sweats, loss of appetite or weight and fatigue that interferes with daily living.
| Characteristic | Bivariable HR (95% CI) |
p- value |
Multivariable HR (95% CI) |
p- value |
|---|---|---|---|---|
| Time-invariant covariates | ||||
| Uganda | 1.00 | 1.00 | ||
| Zimbabwe | 0.48 (0.26, 0.84) | 0.01 | 0.39 (0.18, 0.83) | 0.01 |
| Age at method start (years) | ||||
| 30+ | 1.00 | 1.00 | ||
| 25–29 | 0.96 (0.44, 2.10) | 0.92 | 0.98 (0.45, 2.10) | 0.95 |
| 19–24 | 2.00 (0.96, 4.14) | 0.06 | 1.72 (0.74, 4.01) | 0.21 |
| Time-varying covariates | ||||
| Coital Frequency (typical month in last 3 months) | ||||
| 0–14 acts | 1.00 | N/A | ||
| 15–29 acts | 0.48 (0.20, 1.16) | 0.10 | N/A | |
| 30+ acts | 0.67 (0.15, 2.97) | 0.60 | N/A | |
| Condom use (typical month in last 3 months) | ||||
| Always | 1.00 | 1.00 | ||
| Sometimes | 1.32 (0.36, 4.83) | 0.67 | 1.03 (0.28, 3.79) | 0.97 |
| Never | 2.43 (1.01, 5.85) | 0.05 | 1.26 (0.51, 3.12) | 0.62 |
| No sexual partner | 7.02 (2.94, 16.78) | <0.01 | 7.18 (3.05, 16.88) | <0.01 |
| Participant behavioral risk in last 3 months | 5.81 (1.18, 28.53) | 0.03 | N/A | |
| Current cervical infection (GC or CT) | 2.01 (0.87, 4.66) | 0.10 | 1.99 (0.90, 4.41) | 0.09 |
| CD4 count | ||||
| ≤200 cells/mm3 | 1.00 | 1.00 | ||
| 201–499 cells/mm3 | 0.68 (0.21, 2.21) | 0.52 | 1.22 (0.30, 4.95) | 0.78 |
| ≥500 cells/mm3 | 1.45 (0.49, 4.29) | 0.50 | 1.54 (0.45, 5.33) | 0.49 |