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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Leuk Res. 2013 May 10;37(8):974–979. doi: 10.1016/j.leukres.2013.04.018

Figure 1.

Figure 1

Inhibition of XIAP by ASO upregulates the expression of proteasome component genes in AML cells. A. Western blotting of HL60 and OCI-AML3 cells transfected with XIAP ASO or control oligonucleotide (NSO) confirms reduction of XIAP levels by ASO. B. A heat map shows hierarchically-clustered genes in the Gene Ontology term “proteasomal protein catabolic process” with consistent upregulation following XIAP inhibition by ASO in both HL-60 and OCI-AML3 cells. Each column represents a replicate of ASO treatment compared to a time- and cell line-matched replicate of NSO treatment. Multiple rows for the same gene indicate different probes for that gene. The color bar represents the relative fold-change in gene expression values. hr, hour.