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. Author manuscript; available in PMC: 2014 Jun 27.
Published in final edited form as: Immunity. 2013 Jun 6;38(6):1116–1128. doi: 10.1016/j.immuni.2013.02.022

Figure 7. Newly generated Foxp3+ thymocytes compete for γC-mediated survival signals.

Figure 7

(A) Effect of Foxp3-specific γc-deletion on γc expression (left) and Treg cell number (right) in thymi of 3-4 wk old mice. Mean ± SE of 4-5 mice per group.

(B) Frequency (left) and number (right) of Foxp3+ cells among CD4SP thymocytes in competitive mixed donor chimeras. CD4SP thymocytes of B6 donor origin are γc+ (closed symbols) and displayed in top panels; CD4SP thymocytes of Il2rgfl/fl donor origin are γcfl (open symbols) and displayed in bottom panels. Each circle and square represents an individual mouse. The star indicates intact B6 mice.

***, p<0.0001.

See also Figure S6.