Figure 7.

AAV-orexin increased locomotor activity (LMA) during the dark period. A, The general timing and the amounts of LMA was similar in WT and Atx mice treated with AAV-mCherry. B, Injections of AAV-orexin strongly increased LMA in Atx mice during the dark period. WT mice injected with AAV-orexin showed a less striking increase that did not reach statistical signifi cance. *P < 0.05 compared to WT mice injected with AAV-mCherry. ^#P < 0.05 between Atx mice injected with AAV-mCherry and AAV-orexin. AAV, adeno-associated viral vector; Atx, transgenic (ataxin); WT, wild type.