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. 2013 Jun 5;6:38. doi: 10.1186/1757-2215-6-38

Figure 3.

Figure 3

MR22388 sensitizes ovarian cancer cells to ABT-737. Real time analysis of cellular activity of the combination of MR22388 and ABT-737 was performed using the xCELLigence system. Cells were grown for 24 h, then treated with MR22388 (10, 100 and 1000 nM). 24 h after the beginning of the exposure, IGROV1-R10 (top panel) and SKOV3 (bottom panel) were treated by 10 μM ABT-737. [A,E] Cell index, recorded every 30 min. The results are the mean of three replicates. [B] 4 h after the ABT-737 exposure, IGROV1-R10 DNA content histograms and cellular morphology were assessed. [C] 72 h after ABT-737 exposure, IGROV1-R10 cellular morphology was assessed. PARP and Caspase 3 cleavages were determined by western blot in IGROV1-R10 [D] and SKOV3 cells [F].