Figure 7. Phylogenetic tree of the flanking recombining upstream and downstream sequence breakpoints of CNV regions – pattern of dispersal of breakpoint across taxa and within the genome of an organism.

a–d show the trees for the −1 kb upstream and downstream flanking sequences of the most common CNV event found in all the populations under the study. Figure 7e shows the tree for the −1 kb upstream flanking sequences of rare CNV event found in a population under study. These flanking sequences contain the recombining regions, whose relationship with other orthologous and paralogous sequences can be seen to determine the origin of these sequences and probable other recombining regions. The −1 kb upstream and downstream flanking sequences of the most common CNV events (22,316,500 bp –22,317,500 bp in 15q11.2), (22,474,268 bp –22,475,268 bp in 15q11.2), (22,681,064 bp –22,682,064 bp in 15q11.2), (20,104,479 bp –20,105,479 bp in 14q11.2), (19,801,529–19,802,529 in 14q11.2) found in all the populations under the study were chosen to construct the trees. Figure 7e shows the tree for the −1 kb upstream flanking sequences of rare CNV event found in a population under study. These flanking sequences contain the recombining regions, whose relationship with other orthologous and paralogous sequences can be seen to determine the origin of these sequences and probable other recombining regions.