Table 2. Differentially expressed genes in L. lactis MG1363 cell suspensions (pH 5.1) derived from cultures grown at pH 5.1 (acid stress) or 6.5 (optimal pH).
| Function | Gene | Fold change a | Description of gene product |
|---|---|---|---|
| Carbohydrate metabolism and energy conservation | atpC | 2.8 | F0F1 ATP synthase subunit epsilon |
| atpD | 3.0 | F0F1 ATP synthase subunit beta | |
| atpG | 2.9 | F0F1 ATP synthase subunit gamma | |
| atpA | 2.2 | F0F1 ATP synthase subunit alpha | |
| atpF | 2.5 | F0F1 ATP synthase subunit B | |
| atpB | 2.9 | F0F1 ATP synthase subunit A | |
| atpE | 2.2 | F0F1 ATP synthase subunit C | |
| ldh | 2.6 | L-lactate dehydrogenase | |
| ptcC | 2.4 | Cellobiose-specific PTS system IIC component | |
| gapA | 2.4 | Glyceraldehyde 3-phosphate dehydrogenase | |
| eno | 2.6 | Enolase | |
| gpmA | 2.0 | Phosphoglycerate mutase | |
| pgi | 2.4 | Glucose-6-phosphate isomerise | |
| pyk | 2.4 | Pyruvate kinase | |
| pgk | 2.3 | Phosphoglycerate kinase | |
| llmg_2513 | 6.1 | Putative transport protein | |
| Stress response | recA | 2.0 | Recombinase A |
| dnaK | 2.7 | Molecular chaperone DnaK | |
| clpE | 2.5 | ATP-dependent Clp protease ATP-binding subunit ClpE | |
| groEL | 2.5 | Chaperonin GroEL | |
| clpB | 2.1 | ATP-dependent Clp protease | |
| soda | 2.2 | SodA protein | |
| relA | -2.3 | GTP pyrophosphokinase | |
| llrE | -2.0 | Two-component system regulator llrE |
a Positive values indicate up-regulation and negative values indicate down-regulation. Genes with significantly altered expression (p<0.001) and expression ratio higher than |±2.0| are shown.