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. 2013 Jul 3;8(7):e69069. doi: 10.1371/journal.pone.0069069

Figure 4. Cytokine mRNA expression after RRV infection on DOL 0 or 7.

Figure 4

Expression of IFN-γ (A), TNF-α (B), IL-6 (C), IL-10 (D), and IL-18 (E) mRNA in livers harvested from newborn mice injected with RRV on DOL 0 increases over time as compared to control. In contrast, cytokine levels from livers extracted from mice infected on DOL 7 are more often significantly elevated over control, 2 days post-infection with a general decrease in level as compared to DOL 0 injected mice. Finally, by 7 days post-infection, mRNA expression of all 4 cytokines is higher in mice injected with RRV on DOL 0 as compared to those infected on DOL 7 (* p<0.05 DOL 0 infected vs. DOL 7, # p<0.05 DOL 0 infected vs. uninfected, ◊ p<0.05 DOL 7 infected vs. uninfected).