Figure 10. Bile duct histology of WT and IFN-αβR^{-/ -}mice following RRV infection.

Extrahepatic bile ducts were harvested from WT and IFN-αβR^−/−mice 3, 7 and 14 days post inoculation at early and late time points with RRV and stained with H and E. RRV injection led to obstruction of the lumens of the extrahepatic bile ducts in the early but not the late infected WT mice. In contrast, the lumens of the late infected IFN-αβR^−/−mice were obstructed following RRV injection. Magnification: 10X.