Table 2. Severity of injury as indicated by histologic assessment to the extrahepatic biliary duct following injection with RRV^a.

Days Post Infection	Early Infection	Late Infection
Day 3
Intraepithelial Inflammation	1 (0-1)b	0 (0-0)
Epithelial Damage	1 (0-2)	0 (0-0)
Edema	1 (0-2)	0.5 (0-1)
Submucosal Inflammation	1.5 (1-3)	1(1-1)
Stromal Proliferation	0 (0-0)	0 (0-0)
Total Injury	5 (4-8)	1.5 (1-2)
Day 5
Intraepithelial Inflammation	1 (0-1)	2 (1-2)
Epithelial Damage	1.5 (1-3)	2.5 (2-3)
Edema	1.5 (1-2)	1.5 (1-2)
Submucosal Inflammation	3 (1-3)	2 (2-3)
Stromal Proliferation	0 (0-0)	0 (0-0)
Total Injury	7 (7-9)	9 (8-11)
Day 7
Intraepithelial Inflammation	2 (1-4)	1 (1-2)
Epithelial Damage	2.5 (2-4) *c	1.5 (1-3)
Edema	2 (1-3)*	0 (0-0)
Submucosal Inflammation	2 (1-3)	2 (1-2)
Stromal Proliferation	1 (1-2)	0.5 (0-1)
Total Injury	10 (6-16)*	5 (3-7)
Day 12
Intraepithelial Inflammation	2 (1-3)*	0 (0-1)
Epithelial Damage	2 (1-3)	1 (1–1)
Edema	0 (0-3)	0 (0-0)
Submucosal Inflammation	2 (1-2)	0 (0-0)
Stromal Proliferation	1 (1-2)*	0 (0-0)
Total Injury	7 (4-13)*	2 (2-3)

^a Severity of bile duct injury after inoculation with the RRV, as determined by histologic appearance of the extrahepatic biliary tract.

All sections were graded by a pathologist.

^b Injury scoring is based on an ordinal scale from 0 to 4 Values are expressed as median scores, with ranges indicated in parentheses. The maximum total injury score possible was 20

^c *p < 0.05 when compared with late infection.