Figure 8. Self-emerging clusters and patient subtypes based on speed maxima (m/s).

(A) Representative NC and patients from PD1 and PD2 subgroups grouped the speed maxima differently in the forward and retracting motions as a function of cognitive load condition. The NC maintained consistent separation across conditions in both portions of the pointing gesture yet patients consistently performed worse in the primed cases even though primed-UP was biomechanically equivalent to DEFAULT. PD1 performed the worst with no distinction in the primed cases. Slopes changed systematically with cognitive loads even for biomechanically similar DEFAULT and primed-UP motions. (B) Self emerging subtypes of misclassified trials from the blind clustering k-means separated exactly as the p-value statistics had predicted (see Methods and Results for details).