Table 1.

Allelic and genotypic association analyses. Samples considered were diabetic patients (N=562), non diabetic controls (N=558), diabetic individuals with complications (N=241), centenarians (N=229), diabetic patients with macro-vascular complications (N=64) and diabetic patients with micro-vascular complications (N=110).

	Cohorts	Gene	SNP (ID)	Allele/Genotype	Frequency (%)		p_value	OR (95% CI)	Model
					1	2
Allelic Association	D (1) vs 100+ (2)	ADIPOQ	rs266729	G	24.6	31.6	5.89*10−3	0.71 (0.55-0.91)	/
	D (1) vs CTR (2)	TCF7L2	rs7903146	T	45	37	3.1*10−4	1.37 (1.16-1.63)	/
	D+Co (1) vs CTR (2)	TCF7L2	rs7903146	T	46.1	37	1.66*10−3	1.43 (1.14-1.79)	/
	D (1) vs 100+ (2)	TCF7L2	rs7903146	T	44.8	31.4	1.34*10−6	1.77 (1.40-2.24)	/
	D+Co (1) vs 100+ (2)	TCF7L2	rs7903146	T	45	31.4	1.06*10−6	1.78 (1.41-2.25)	/
	D+macroCo (1) vs 100+ (2)	TCF7L2	rs7903146	T	50	31.4	1.13*10−4	2.177 (1.46-3.24)	/
	D+microCo (1) vs 100+ (2)	TCF7L2	rs7903146	T	46	31.4	2.64*10−4	1.85 (1.33-2.57)	/
Genotypic association	D (1) vs 100+ (2)	ADIPOQ	rs266729	G/C	36.6	50.7	4.19*10−4	0.56 (0.41-0.77)	Over dominant
	D (1) vs CTR (2)	TCF7L2	rs7903146	TC/TT	58.9	70.0	1.41*10−4	1.63 (1.26-2.09)	Dominant
	D+Co (1) vs CTR (2)	TCF7L2	rs7903146	TC/TT	58.8	71.9	5.96*10−4	1.79 (1.28-2.52)	Dominant
	D (1) vs 100+ (2)	TCF7L2	rs7903146	CC	30	47.5	9.07*10−7	1.78 (1.41-2.26)	Log-additive
				TC	50	42.1
				TT	20	10.4
	D+Co (1) vs 100+ (2)	TCF7L2	rs7903146	CC	28.1	47.5	5.47*10−6	1.89 (1.43-2.50)	Log-additive
				TC	51.1	42.1
				TT	20.8	10.4
	D+macroCo (1) vs 100+ (2)	TCF7L2	rs7903146	CC	23.4	47.5	1.54*10−4	2.18 (1.45 −3.29)	Log-additive
				TC	53.1	42.1
				TT	23.4	10.4
	D+microCo (1) vs 100+ (2)	TCF7L2	rs7903146	CC	29.1	47.5	3.30*10−4	1.84 (1.31 −2.58)	Log-additive
				TC	50.0	42.1
				TT	20.9	10.4