Table 1. Comparison of Age-Stratified Senior and Frail Elderly Donors and Associations with Previous Cancer Status.
Characteristic | Seniors | Frail elderly | Pval | Previous cancer status |
Pval | |
---|---|---|---|---|---|---|
Negative | Positive | |||||
Sample size | 24 | 26 | 148 | 23 | ||
Age range (median) | 68–76 (71) | 67–80 (74) | 61–99 (84) | 68–99 (86) | ||
CD45+ leukocytes | 6811 ± 961 | 5440 ± 298 | NS | 5844 ± 257 | 6077 ± 471 | NS |
Monocytes | 5.29 ± 0.41 | 4.55 ± 0.30 | NS | 5.42 ± 0.37 | 5.45 ± 0.16 | NS |
MDSCs | ||||||
CD33+HLA-DR− | 0.29 ± 0.04 | 0.33 ± 0.05 | NS | 0.35 ± 0.02 | 0.56 ± 0.10 | 0.031 |
CD11b+CD15+ subset | 0.16 ± 0.04 | 0.24 ± 0.05 | 0.046 | 0.23 ± 0.02 | 0.44 ± 0.09 | 0.030 |
Means and se are presented. CD45+ leukocytes are presented as per microliter of whole blood, whereas values for all other subsets are relative to values established for CD45+ leukocytes. Comparisons were performed by linear regression on log-transformed values, adjusting for age, sex, and cohort (where applicable, see Materials and Methods). Comparison-wise P values (Pval) are presented.