Table 1.
Group differences in hippocampus and BFCS grey matter volume as diagnostic markers
| HE | vmAD | AD | vmAD vs HE | AD vs HE | |||
|---|---|---|---|---|---|---|---|
| p | AUC | p | AUC | ||||
| Hippocampus (bilat.) | 3088±268 | 2770±354 | 2648±450 | <.001 | .78 | <.001 | .81 |
| L Hippocampus | 1494±142 | 1353±174 | 1288±207 | <.001 | - | <.001 | - |
| R Hippocampus | 1594±140 | 1.417±204 | 1359±256 | <.001 | - | <.001 | - |
| BFCS (bilat.) | 729±84 | 679±78 | 623±100 | <.001 | .69 | <.001 | .81 |
| L BFCS | 380±44 | 356±44 | 327±54 | <.001 | - | <.001 | - |
| R BFCS | 349±43 | 324±40 | 296±53 | <.001 | - | <.001 | - |
| Comp (bilat.) | 851±75 | 777±81 | 728±103 | <.001 | .76 | <.001 | .87 |
| L Comp | 435±40 | 400±43 | 374±51 | <.001 | - | <.001 | - |
| R Comp | 416±38 | 377±44 | 354±58 | <.001 | - | <.001 | - |
Values for hippocampus and BFCS (basal forebrain cholinergic system) are mean TIV-normalised grey matter volumes in mm3 ± standard deviation. Values for Comp (composite marker) are calculated as the arithmetic mean of the TIV-normalised BFCS and hippocampus GM volumes divided by their respective mask size. P-values indicate the statistical significance of differing group mean values as assessed by group-wise 2-sample t-tests. AD = group of clinically manifest Alzheimer´s disease. R/L = right/left. AUC = Area under the curve (of a ROC-analysis). TIV = total intracranial volume. vmAD = group with questionable/very mild Alzheimer´s disease. HE = healthy elderly.