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. Author manuscript; available in PMC: 2013 Jul 4.
Published in final edited form as: Nat Cell Biol. 2013 Jan;15(1):17–27. doi: 10.1038/ncb2646

Figure 2. Luminal filling is not due to a lack of apoptosis.

Figure 2

(a, b) Time course of lumen development over 7 days in WT and β1-KO acini, treated with 4OHT at time of plating. Cells expressing caspase 3 (arrows) were not restricted to the centre of acini. Bar: 10μm.

(c) Immunoblotting shows loss of β1-integrin and a small increase in caspase 3 in 4OHT-treated cells.

(d) zVAD treatment of ICR MECs did not prevent lumen formation. Bar: 10μm.

(e) Scribble staining revealed intact intercellular adhesions in WT and β1-KO acini. Arrows indicate Scribble in internal cells. Bar: 10μm.

See also Supplementary Fig. 3, 8.

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