Figure 3.
Dose–response of lipopolysaccharide (LPS) induced preterm labour. CD1 mice received an intrauterine injection of vehicle or LPS at E16 and were allowed to deliver, (n = 3–10 per treatment group). No vehicle control mice delivered preterm and LPS induced preterm labour in a dose–response effect, (a). No surviving pups were seen at an LPS dose of >10 μg (b). For statistical analysis, one-way analysis of variance with Dunnett's post hoc test comparing all groups to the vehicle control was used; **P < 0.01, ***P < 0.001.