Figure 9.
The effect of CRTH2 agonists on circular muscle contractility. CD1 mice were killed on E15–16 and myometrial tissue was harvested to mount on the myograph in the circular orientation (n = 3). A cumulative dose–response of CRTH2 agonists or vehicle was performed and the average area under the curve was determined. An inhibition in myometrial contractility was seen with Pyl A, but no effect with 15dPGJ2 or DK-PGD2. Graphs showing the effects of the CRTH2 agonists are shown (a,c,e), with representative traces of myometrial contractility (b,d,f). V = vehicle, PA = Pyl A. For statistical analysis, analysis of variance of repeated measures was used with Dunnett's multiple comparison test; **P < 0.01, ***P < 0.001.