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. 2013 Mar 15;6(4):1021–1030. doi: 10.1242/dmm.011908

Fig. 2.

Fig. 2.

Effect of erythropoietin (EPO) on the cardiac dysfunction in endotoxemic β-common receptor knockout (βcR KO) mice. (A–D) Representative M-mode echocardiograms (A), and percentage ejection fraction (B), fractional shortening (C) and fractional area of change (D) 18 hours subsequent to sham-operation or lipopolysaccharide (LPS) administration. (E,F) Volume-pressure curves were generated from isolated Langendorff-perfused hearts to assess alterations in isovolumic left ventricular developed pressure (LVDP) in response to 5 μl incremental increases in balloon volume (E) and in response to 30 μl (maximum response) volume loading (F), 16–18 hours subsequent to sham operation or LPS administration. Mice received either LPS (9 mg/kg i.p.) or vehicle (5 ml/kg 0.9% saline i.p.). At 1 hour after induction of endotoxemia, mice were treated either with EPO (1000 IU/kg s.c.) or vehicle (10 ml/kg 0.9% saline s.c.). (B–D) Sham + vehicle (n=9); sham + EPO (n=3); LPS + vehicle (n=14); LPS + EPO (n=25). (E,F) Sham + vehicle (n=11); LPS + vehicle (n=9); LPS + EPO (n=9). Data are expressed as means ± s.e.m. for n number of observations. ★P<0.05 versus LPS + vehicle; •P<0.05 sham + vehicle versus LPS + vehicle.