Table 2.
MrOS: Characteristics of subjects with normocalcemic hypoparathyroidism vs normal PTHa
Parameter | Normocalcemic Hypoparathyroidism (n = 26) | Normal PTH (n = 2224) | P Value |
---|---|---|---|
Age, y | 73.4 ± 6 | 73.5 ± 6 | .95 |
Height, cm | 174.5 ± 7 | 174.3 ± 7 | .69 |
Weight, kg | 85.7 ± 12 | 83.4 ± 13 | .31 |
BMI, kg/m2 | 28.2 ± 4 | 27.4 ± 4 | .43 |
White, % | 23 (88.5) | 2031 (91.3) | .49 |
Daily calcium supplementation, mg | 632 ± 520 | 344 ± 440 | .02 |
Daily calcium supplementation >1000 mg, % | 14 (53.9) | 508 (22.8) | .0006 |
Daily vitamin D supplementation, IU | 264 ± 230 | 227 ± 200 | .36 |
Serum calcium adjusted for albumin, mg/dL | 9.5 ± 0.4 | 9.3 ± 0.3 | .003 |
Intact PTH, pg/mLb | 12.2 ± 2 | 32.5 ± 11 | <.0001 |
Serum phosphorus, mg/dL | 3.5 ± 0.4 | 3.2 ± 0.4 | .0001 |
25-Hydroxyvitamin D, ng/mL | 28.8 ± 8 | 26.8 ± 9 | .21 |
Procollagen I N-terminal propeptide, ng/mL | 29.8 ± 11 | 38.4 ± 25 | .15 |
C-terminal telopeptide, ng/mL | 0.3 ± 0.2 | 0.4 ± 0.2 | .25 |
Tartrate-resistant acid phosphatase 5b, U/L | 3.1 ± 0.9 | 3.2 ± 1.0 | .77 |
SHBG, nmol/L | 50.2 ± 19 | 49.4 ± 20 | .67 |
Testosterone, ng/mL | 395.0 ± 172 | 406.2 ± 171 | .92 |
Free testosterone, ng/mL | 7.5 ± 3 | 7.9 ± 3 | .55 |
Estrogen, pg/mL | 19.9 ± 12 | 22.5 ± 9 | .09 |
Free estrogen, pg/mL | 0.5 ± 0.2 | 0.5 ± 0.2 | .32 |
Lumbar spine BMD, g/cm2 | 1.2 ± 0.12 | 1.2 ± 0.3 | .94 |
Femoral neck BMD, g/cm2 | 0.8 ± 0.1 | 0.8 ± 0.1 | .51 |
Single-slice integral BMD, average L1L2, g/mL | 0.21 ± 0.03 | 0.21 ± 0.04 | .48 |
Single-slice trabecular BMD, average L1L2, g/mL | 0.11 ± 0.04 | 0.11 ± 0.04 | .89 |
Femoral neck, integral BMD, g/mL | 0.29 ± 0.05 | 0.29 ± 0.06 | .93 |
Femoral neck, trabecular BMD, g/mL | 0.08 ± 0.04 | 0.07 ± 0.05 | .41 |
Results are shown as mean ± SD. Values in bold remain significant with Bonferroni correction.
By definition, PTH was <14 pg/mL in the subjects with normocalcemic hypoparathyroidism.