Figure 2.

GIPC1–MYO6 complex-dependent trafficking of endocytic vesicles. GIPC1 is an adaptor protein that can interact with trafficking cargoes, while MYO6 is a motor protein that can move along actin filaments from the plus (barbed) end near the plasma membrane to the minus (pointed) end in the cytoplasm. Representative cargoes of the GIPC1–MYO6 complex are classified into receptor tyrosine kinases (RTKs; IGF1R and NTRK1), G protein-coupled receptors (GPCRs; ADRB1, DRD2 and LHCGR), single-span transmembrane (TM) proteins (TGFβR3, endoglin, LRP1, LRP2, integrin α5, NRP1, SDC4 and SEMA4C), tetra-span TM protein (VANGL2) and cytosolic signaling regulators (APPL1 and RGS19). The GIPC1–MYO6 complex is directly involved in trafficking and signaling and is indirectly involved in the recycling of its cargoes.